Mercedes-Benz S450 Insurance Rates: 2025 Cost and Comparisons

How much does Mercedes-Benz S450 insurance cost? We compared average car insurance rates for the two-wheel drive and 4Matic S450 models to see how prices ranked against other luxury models.

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  • Mercedes S450 insurance rates average $3,404 per year or $1,702 for a semi-annual policy, but can vary based on the age of the rated driver.
  • The S450 Sedan trim level costs an average of $3,370 per year to insure, while the 4Matic Sedan trim costs $3,436 for an annual policy.
  • Out of 21 models in the 2021 large luxury car segment, the S450 ranks 11th for car insurance cost.

How much does Mercedes S450 insurance cost?

Mercedes-Benz S450 car insurance costs an average of $3,404 per year, which is equal to $284 a month. Liability and medical payments insurance will cost about $726 a year, collision insurance is about $1,824, and the remaining comprehensive coverage will cost about $854.

The following chart shows how Mercedes S450 insurance costs vary based on a variety of driver ages and comprehensive and collision deductibles. The annual policy cost values shown range from $2,312 per year for a driver age 60 with deductibles of $1,000 to a high policy cost of $8,182 each year for a driver age 20 with low physical damage deductibles.

Average 2021 Mercedes-Benz S450 car insurance premiums for different driver ages and policy deductibles.
Figure 1: Average 2021 Mercedes-Benz S450 car insurance premiums for different driver ages and policy deductibles. Rates updated on October 24, 2025.

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Data Methodology: Average premiums are based on a 2021 model year Mercedes-Benz S450. Rates assume a clean driving record and no claims or at-fault accidents. Comprehensive and collision coverage is included as well as UM/UIM and medical payments coverage. Premium amounts are averaged across all trim levels.

2021 Mercedes-Benz S450 Insurance Cost by Driver Age and Deductibles
Driver Age Policy Deductible Annual Premium Cost Per Month
20-Year-Old$1,000$5,702$475
$500$6,906$576
$250$8,182$682
30-Year-Old$1,000$2,994$250
$500$3,652$304
$250$4,342$362
40-Year-Old$1,000$2,796$233
$500$3,404$284
$250$4,038$337
50-Year-Old$1,000$2,464$205
$500$2,986$249
$250$3,534$295
60-Year-Old$1,000$2,312$193
$500$2,802$234
$250$3,316$276

Data Methodology: Rated driver has no driving violations or at-fault accidents in the prior three years. Uninsured Motorist (UM), Underinsured Motorist (UIM) and medical payments coverages are included. Premium is averaged for all trim levels available for the 2021 Mercedes-Benz S450. Updated October 24, 2025

The following table shows average insurance rates for a Mercedes S450 for the 2018 to 2021 model years.

Mercedes-Benz S450 Insurance Cost by Model Year
Model Year and Vehicle Driver Age 20 Driver Age 40 Driver Age 60
2021 Mercedes-Benz S450$6,906$3,404$2,802
2020 Mercedes-Benz S450$6,678$3,292$2,710
2019 Mercedes-Benz S450$5,924$2,924$2,408
2018 Mercedes-Benz S450$5,554$2,748$2,266

Data Methodology: Rated driver is a 40-year-old married male with no driving violations or at-fault accidents in the prior three years. Comprehensive and collision deductibles are $500 and UM/UIM and medical payments coverages are included. Premiums are averaged for all Mercedes-Benz S450 trim levels for each model year. Updated October 24, 2025

Average insurance rates for 2018 to 2021 Mercedes-Benz S450 models for drivers age 20, 40 and 60
Average insurance rates for 2018 to 2021 Mercedes-Benz S450 models for drivers age 20, 40 and 60

The table below displays the average policy cost for the different trim levels available on the 2021 S450.

2021 Mercedes-Benz S450 Insurance Rates by Trim Level
2021 Mercedes-Benz S450 Trim Level Annual Premium Cost Per Month
Sedan$3,370$281
4Matic Sedan$3,436$286

Data Methodology: Rated driver is a 40-year-old married male with no driving violations or at-fault accidents in the prior three years. Comprehensive and collision deductibles are $500 and UM/UIM and medical payments coverages are included. Updated October 24, 2025

Insurance cost by trim level for a 2021 Mercedes-Benz S450 ranging from the Sedan model at $3,370 per year to the 4Matic Sedan model at $3,436
Insurance cost by trim level for a 2021 Mercedes-Benz S450 ranging from the Sedan model at $3,370 per year to the 4Matic Sedan model at $3,436

How does Mercedes S450 insurance cost rank?

The Mercedes-Benz S450 ranks 11th out of 21 total vehicles in the 2021 full-size luxury sedan segment for most affordable insurance cost. The S450 costs an average of $3,404 per year for a full coverage policy and the class median price is $3,400 per year, a difference of just $4 per year.

When compared to other popular luxury sedans, car insurance rates for a Mercedes-Benz S450 cost $990 more per year than the Audi A5, $136 less than the BMW 740i, and $330 less than the Porsche Panamera.

The table below shows how car insurance rates for a S450 compare to the all other large luxury cars like the Infiniti Q60, Audi A8, and the Genesis G90.

Mercedes-Benz S450 Insurance vs Large Luxury Cars
Rank Make and Model Annual Premium Difference
1Audi A5$2,414-$990
2Volvo S90$2,582-$822
3Lexus LS 500H$2,904-$500
4Kia K900$2,958-$446
5Lexus LS 500$3,054-$350
6Mercedes-Benz AMG E53$3,102-$302
7Infiniti Q60$3,114-$290
8Genesis G90$3,122-$282
9Mercedes-Benz AMG CLS53$3,190-$214
10BMW 840i$3,262-$142
11Mercedes-Benz S450$3,404--
12BMW M850i$3,424$20
13BMW 740i$3,540$136
14BMW 850i$3,568$164
15Mercedes-Benz E63 AMG$3,586$182
16Porsche Panamera$3,734$330
17Audi A8$3,794$390
18Mercedes-Benz S560$3,830$426
19BMW 750i$3,846$442
20BMW M760i$4,340$936
21Mercedes-Benz AMG S63$4,640$1,236

Data Methodology: Rated driver is a 40-year-old married male with no driving violations or at-fault accidents in the prior three years. Comprehensive and collision deductibles are $500 and UM/UIM and medical payments coverages are included. Premiums are averaged for all trim levels for each vehicle from the 2021 model year. Updated October 24, 2025

At $3,404 per year, insurance cost for a 2021 Mercedes-Benz S450 ranks 11th out of 21 models in the large luxury car segment
At $3,404 per year, insurance cost for a 2021 Mercedes-Benz S450 ranks 11th out of 21 models in the large luxury car segment